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New NIH award on cardiac modeling software infrastructure

August 4, 2025

We are thrilled to announce that we have been awarded a two-year R03 grant through the NIH’s Building Sustainable Software Tools for Open Science program to advance Cardinal, a new open-source software platform for simulating all major aspects of heart function. Cardinal will give researchers a powerful, physics-based framework for integrating clinical and experimental data to better understand disease mechanisms, test interventions, and develop personalized treatment strategies. This project will optimize Cardinal’s computational performance, improve portability across computing environments, and expand community resources—enabling more accurate, scalable, and accessible cardiac digital twin models for research and clinical translation.

New NIH award on leaflet thrombosis in bioprosthetic heart valves

December 24, 2021

We are thrilled to announce that we just received notification of a new $2.7M NIH R01 award for a project that aims to create and use experimentally and clinically validated computer models to understand the mechanisms that lead to subclinical leaflet thrombosis in bioprosthetic heart valves following aortic valve replacement, and thereby improve risk stratification and device selection for patients who require aortic valve replacement to treat aortic stenosis.

This is a collaborative project that will be carried out with teams of researchers at the University of California, Irvine (PI: Arash Kheradvar) and the University of Utah (PI: Aaron Fogelson) along with collaborators here at UNC School of Medicine.

New NSF software infrastructure award

August 14, 2019

We are trilled to announce that we just received notification of a new $1.3M award through the NSF Cyberinfrastructure for Sustained Scientific Innovation program. This project will develop multiphase and low Mach number flow simulation capabilities in the IBAMR software and will re-engineer IBAMR to scale to 1000’s of cores and beyond. These capabilities will enable specific applications, including biological applications along with wave-energy converter devices and additive manufacturing (3D printing).

This is a collaborative project that will be carried out with teams of researchers at Northwestern University (PI: Neelesh Patankar), San Diego State University (PI: Amneet Bhalla), and University at Buffalo (PI: Matt Knepley).

New award on modeling IVC filters with the FDA

September 7, 2018

We are trilled to announce that we just received notification of a new $160K research award on developing models of IVC filters through the NSF/FDA Scholar-in-Residence at the FDA program. This project is in collaboration with Brent Craven in the Division of Applied Mechanics in the Center for Devices and Radiological Health at the FDA.

New award on modeling atrial fibrillation

July 23, 2018

We are trilled to announce that we just received notification of a new $2.8M research award on developing multiscale models of blood clotting in atrial fibrillation through the NIH-led multiagency Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental and Clinical Research program. The project team includes investigators at Duke University (PI: Craig Henriquez) and the University of Utah (PI: Aaron Fogelson).